Maturational Changes in Airway Smooth Muscle Structure-Function Relationships
نویسندگان
چکیده
منابع مشابه
The importance of maturational studies in airway smooth muscle.
ASTHMA AFFECTS 17.7 million Americans, 5 million of them children (41). Its incidence has more than doubled in the general population since 1980, with a disproportionate increase in children under the age of 4 (41). Measures of the yearly burden of this disease, 5,500 deaths (31), nearly $6 billion in direct treatment costs, and a total of $25 billion in all costs, including lost productivity, ...
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Airway reactivity has been shown to vary with age; however, the mechanism(s) underlying this process remain unidentified. To elucidate the role of ontogenetic changes in phosphoinositide-linked signal transduction, we examined whether age-related differences in tracheal smooth muscle (TSM) contractility to carbachol (CCh) are associated with developmental changes in the production and metabolis...
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Airway smooth muscle (ASM) cells in culture stiffen when exposed to contractile agonists. Such cell stiffening may reflect activation of the contractile apparatus as well as polymerization of cytoskeletal biopolymers. Here we have assessed the relative contribution of these mechanisms in cultured ASM cells stimulated with serotonin (5-hydroxytryptamine; 5-HT) in the presence or absence of drugs...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1992
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199202000-00012